Hydrochloric Acid → (3S,4S)-1-[(S)-2-(4-Amino-piperidin-1-yl)-1-methyl-ethyl]-3-methyl-piperidin-4-ol tri-hydrochloride

HRID 2267713Notes

Reaction equation

HRID 2267713 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][C@@H:15]([N:17]2[CH2:22][CH2:21][C@H:20]([OH:23])[C@@H:19]([CH3:24])[CH2:18]2)[CH3:16])[CH2:10][CH2:9]1)(C)(C)C.[ClH:26].O1CCOCC1.Cl.Cl.Cl.CC1CCN(CCN2CCC(N)CC2)CC1>>[ClH:26].[ClH:26].[ClH:26].[NH2:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][C@@H:15]([N:17]2[CH2:22][CH2:21][C@H:20]([OH:23])[C@@H:19]([CH3:24])[CH2:18]2)[CH3:16])[CH2:10][CH2:9]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 668413221-[2-(4-Methyl-piperidin-1-yl)-ethyl]-piperidin-4-ylamine tri-hydrochlorideHCID 66844927{1-[(S)-2-((3S,4S)-4-Hydroxy-3-methyl-piperidin-1-yl)-propyl]-piperidin-4-yl}-carbamic acid tert-butyl ester

Product 1

HCID 66841745(3S,4S)-1-[(S)-2-(4-Amino-piperidin-1-yl)-1-methyl-ethyl]-3-methyl-piperidin-4-ol tri-hydrochloride

Procedure

It is prepared by BOC-cleavage of tert-butyl ester 59 (0.666 g, 1.95 mmol) with 4M-HCl in dioxane (2.93 ml, 11.72 mmol) as described for amine 7.

Sources & evidence

ORD record
ord-03630a330bcf4de8b1c6b7578dbcf72e
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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