HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 66841583, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | {1-[(1S,9aR)-1-(Octahydro-quinolizin-1-yl)methyl]-piperidin-4-yl}-carbamic acid tert-butyl ester | HCID 59600141 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 66841583 | HCID 66841583 | — |
Reaction Steps
The ester 62 (3.8 g, 10.8 mmol) is dissolved in 15 ml of dioxane and after addition of 70 ml of a 4M solution of HCl in dn of HCl in dioxan the mixture is stirred for 4 hours at RT. The product is filtered off and is used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858781B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-edf42419578243e3af85b8d9ebf9fc76 |
| Source note | uspto-grants-2010_12 |