Hydrochloric Acid → HCID 66841583, compound

HRID 2267716Notes

Reaction equation

HRID 2267716 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][C@H:15]2[C@@H:24]3[N:19]([CH2:20][CH2:21][CH2:22][CH2:23]3)[CH2:18][CH2:17][CH2:16]2)[CH2:10][CH2:9]1)(C)(C)C.[ClH:26]>O1CCOCC1>[ClH:26].[ClH:26].[ClH:26].[C@H:15]1([CH2:14][N:11]2[CH2:12][CH2:13][CH:8]([NH2:7])[CH2:9][CH2:10]2)[C@@H:24]2[N:19]([CH2:20][CH2:21][CH2:22][CH2:23]2)[CH2:18][CH2:17][CH2:16]1

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 59600141{1-[(1S,9aR)-1-(Octahydro-quinolizin-1-yl)methyl]-piperidin-4-yl}-carbamic acid tert-butyl ester

Product 1

HCID 66841583HCID 66841583, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

The ester 62 (3.8 g, 10.8 mmol) is dissolved in 15 ml of dioxane and after addition of 70 ml of a 4M solution of HCl in dn of HCl in dioxan the mixture is stirred for 4 hours at RT. The product is filtered off and is used in the next step without further purification.

Workup

  1. filtrationThe product is filtered off
  2. customis used in the next step without further purification

Sources & evidence

ORD record
ord-edf42419578243e3af85b8d9ebf9fc76
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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