4-(3-methyl-butyloxy)-1H-indole-2-carboxylic acid → 4-(3-Methyl-butyloxy)-1H-indole-2-carboxylic acid {1-[2-(4-hydroxy-piperidin-1-yl)-ethyl]-piperidin-4-yl}-amide dihydrochloride

HRID 2267756Notes

Reaction equation

HRID 2267756 reaction equation
[CH3:1][CH:2]([CH3:18])[CH2:3][CH2:4][O:5][C:6]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:7]=1[CH:8]=[C:9]([C:15]([OH:17])=O)[NH:10]2.[ClH:19].Cl.Cl.[NH2:22][CH:23]1[CH2:28][CH2:27][N:26]([CH2:29][CH2:30][N:31]2[CH2:36][CH2:35][CH:34]([OH:37])[CH2:33][CH2:32]2)[CH2:25][CH2:24]1>>[ClH:19].[ClH:19].[OH:37][CH:34]1[CH2:33][CH2:32][N:31]([CH2:30][CH2:29][N:26]2[CH2:25][CH2:24][CH:23]([NH:22][C:15]([C:9]3[NH:10][C:11]4[C:7]([CH:8]=3)=[C:6]([O:5][CH2:4][CH2:3][CH:2]([CH3:1])[CH3:18])[CH:14]=[CH:13][CH:12]=4)=[O:17])[CH2:28][CH2:27]2)[CH2:36][CH2:35]1

Participants

3

Reactant 2

HCID 668415294-(3-methyl-butyloxy)-1H-indole-2-carboxylic acidHCID 66841786HCID 66841786, compound

Product 1

HCID 668415144-(3-Methyl-butyloxy)-1H-indole-2-carboxylic acid {1-[2-(4-hydroxy-piperidin-1-yl)-ethyl]-piperidin-4-yl}-amide dihydrochloride

Procedure

This compound is synthesized analogously to Example 1 from 4-(3-methyl-butyloxy)-1H-indole-2-carboxylic acid (84) (preparation see below) and amine 21.

Sources & evidence

ORD record
ord-6f29455efa974925896f518d95c9bc08
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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