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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2267756Generated: October 30, 2026

4-(3-methyl-butyloxy)-1H-indole-2-carboxylic acid → 4-(3-Methyl-butyloxy)-1H-indole-2-carboxylic acid {1-[2-(4-hydroxy-piperidin-1-yl)-ethyl]-piperidin-4-yl}-amide dihydrochloride

https://huagongshe.com/reaction/2267756

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(3-methyl-butyloxy)-1H-indole-2-carboxylic acidHCID 66841529—
ReactantHCID 66841786HCID 66841786—
Product4-(3-Methyl-butyloxy)-1H-indole-2-carboxylic acid {1-[2-(4-hydroxy-piperidin-1-yl)-ethyl]-piperidin-4-yl}-amide dihydrochlorideHCID 66841514—

Reaction Steps

This compound is synthesized analogously to Example 1 from 4-(3-methyl-butyloxy)-1H-indole-2-carboxylic acid (84) (preparation see below) and amine 21.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07858781B2
Source datasetuspto-grants-2010_12
ORD IDord-6f29455efa974925896f518d95c9bc08
Source noteuspto-grants-2010_12