反应详情

温度

85 °C

112 (1.2 g, 2.6 mmol) is dissolved in 30 ml of a 1:1:1 mixture of THF, ethanol and water. And after addition of KOH pellets (742 mg, 13.2 mmol) the mixture is stirred for 2 h (TLC control) at 85° C. Then the organic solvent are removed under reduced pressure. The residue is cooled to 0° C. and treated with 2M HCl. The crude product is filtered off and dried under high vacuum. The crude product (800 mg) is recrystallized from ethyl acetate.

1. customThen the organic solvent are removed under reduced pressure
2. temperatureThe residue is cooled to 0° C.
3. additiontreated with 2M HCl
4. filtrationThe crude product is filtered off
5. customdried under high vacuum
6. customThe crude product (800 mg) is recrystallized from ethyl acetate