HCID 66841507, compound → 4-(4,6-Dimethoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {1-[2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-ethyl]-piperidin-4-yl}-amide dihydrochloride

HRID 2267853Notes

Reaction equation

HRID 2267853 reaction equation
[ClH:1].Cl.[C@H]1(C[N:14]2[CH2:19][CH2:18][CH:17]([NH:20][C:21]([C:23]3[NH:24][C:25]4[C:30]([CH:31]=3)=[C:29]([O:32][CH2:33][C:34]3[C:38]5[C:39]([O:45][CH3:46])=[CH:40][C:41]([O:43][CH3:44])=[CH:42][C:37]=5[O:36][CH:35]=3)[CH:28]=[CH:27][CH:26]=4)=[O:22])[CH2:16][CH2:15]2)[C@@H]2N(CCCC2)CCC1.Cl.Cl.Cl.NC1CCN([CH2:57][CH2:58][N:59]2[CH2:64][CH2:63][C@H:62]([OH:65])[C@@H:61]([CH3:66])[CH2:60]2)CC1>>[ClH:1].[ClH:1].[OH:65][C@H:62]1[CH2:63][CH2:64][N:59]([CH2:58][CH2:57][N:14]2[CH2:19][CH2:18][CH:17]([NH:20][C:21]([C:23]3[NH:24][C:25]4[C:30]([CH:31]=3)=[C:29]([O:32][CH2:33][C:34]3[C:42]5[C:41]([O:43][CH3:44])=[CH:40][C:39]([O:45][CH3:46])=[CH:38][C:37]=5[O:36][CH:35]=3)[CH:28]=[CH:27][CH:26]=4)=[O:22])[CH2:16][CH2:15]2)[CH2:60][C@@H:61]1[CH3:66]

Participants

3

Reactant 2

HCID 66841507HCID 66841507, compoundHCID 66841748(3S,4S)-1-[2-(4-Amino-piperidin-1-yl)-ethyl]-3-methyl-piperidin-4-ol trihydrochloride

Product 1

HCID 668415274-(4,6-Dimethoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {1-[2-((3S,4S)-4-hydroxy-3-methyl-piperidin-1-yl)-ethyl]-piperidin-4-yl}-amide dihydrochloride

Procedure

This compound is synthesized from 4-(4,6-dimethoxy-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid (126, see example 99) and amine 14 analogously to the method described in example 1.

Sources & evidence

ORD record
ord-da50ef41115845bcbc2e44dba316756f
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

Loading…