HCID 66841346, compound → 4-(4-Methoxy-phenyl)-1H-indole-2-carboxylic acid {1-[(S)-2-(4-hydroxy-piperidin-1-yl)-propyl]-piperidin-4-yl}-amide

HRID 2267862Notes

Reaction equation

HRID 2267862 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:17]=[CH:16][CH:15]=[C:14]3[C:10]=2[CH:11]=[C:12]([C:18](O)=[O:19])[NH:13]3)=[CH:5][CH:4]=1.Cl.Cl.Cl.[NH2:24][CH:25]1[CH2:30][CH2:29][N:28]([CH2:31][C@@H:32]([N:34]2[CH2:39][CH2:38][CH:37]([OH:40])[CH2:36][CH2:35]2)[CH3:33])[CH2:27][CH2:26]1>>[OH:40][CH:37]1[CH2:36][CH2:35][N:34]([C@@H:32]([CH3:33])[CH2:31][N:28]2[CH2:27][CH2:26][CH:25]([NH:24][C:18]([C:12]3[NH:13][C:14]4[C:10]([CH:11]=3)=[C:9]([C:6]3[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=3)[CH:17]=[CH:16][CH:15]=4)=[O:19])[CH2:30][CH2:29]2)[CH2:39][CH2:38]1

Participants

3

Reactant 2

HCID 66841346HCID 66841346, compoundHCID 66841433HCID 66841433, compound

Product 1

HCID 596001864-(4-Methoxy-phenyl)-1H-indole-2-carboxylic acid {1-[(S)-2-(4-hydroxy-piperidin-1-yl)-propyl]-piperidin-4-yl}-amide

Procedure

This compound is synthesized analogously to example 1 from 4-(4-methoxy-phenyl)-1H-indole-2-carboxylic acid, 128 (see example 141) and amine 50.

Sources & evidence

ORD record
ord-8b30265adcc14f05ace6fb43a0c2fc1e
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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