Lithium Hydroxide → HCID 66841878, compound

HRID 2267890Notes

Reaction equation

HRID 2267890 reaction equation
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[C:12]([O:15][C:16]1[CH:21]=[CH:20][C:19]([F:22])=[C:18]([F:23])[CH:17]=1)[CH:11]=[CH:10][CH:9]=2)=[O:5])C.[Li+].[OH-]>CO.O>[F:23][C:18]1[CH:17]=[C:16]([CH:21]=[CH:20][C:19]=1[F:22])[O:15][C:12]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:13]=1[CH:14]=[C:6]([C:4]([OH:5])=[O:3])[NH:7]2

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 66841670HCID 66841670, compound

Product 1

HCID 66841878HCID 66841878, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

152 (380 mg, 1.2 mmol) is dissolved in 10 ml of methanol and treated with a solution of LiOH (57 mg, 2.4 mmol) in 5 ml of water. The mixture is stirred at room temperature for 18 hours. After evaporation, the crude product is acidified at 0° C. with 2M HCl and extracted with ethyl acetate. The organic layers are dried over sodium sulphate and evaporated.

Workup

  1. customAfter evaporation
  2. customis acidified at 0° C. with 2M HCl
  3. extractionextracted with ethyl acetate
  4. dry with materialThe organic layers are dried over sodium sulphate
  5. customevaporated

Sources & evidence

ORD record
ord-42652848e220455d880f04fea855cc1c
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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