(1-Methyl-3-piperidyl)methanol → 4-Isobutoxy-1H-indole-2-carboxylic acid [1-(1-methyl-piperidin-3-ylmethyl)-piperidin-4-yl]-amide

HRID 2267902Notes

Reaction equation

HRID 2267902 reaction equation
Cl.Cl.[CH:3]1([CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([NH:20][C:21]([C:23]3[NH:24][C:25]4[C:30]([CH:31]=3)=[C:29]([O:32][CH2:33][CH:34]([CH3:36])[CH3:35])[CH:28]=[CH:27][CH:26]=4)=[O:22])[CH2:16][CH2:15]2)[CH:12]2[N:7]([CH2:8]CCC2)[CH2:6][CH2:5][CH2:4]1.CN1CCCC(CO)C1>>[CH3:8][N:7]1[CH2:6][CH2:5][CH2:4][CH:3]([CH2:13][N:14]2[CH2:15][CH2:16][CH:17]([NH:20][C:21]([C:23]3[NH:24][C:25]4[C:30]([CH:31]=3)=[C:29]([O:32][CH2:33][CH:34]([CH3:36])[CH3:35])[CH:28]=[CH:27][CH:26]=4)=[O:22])[CH2:18][CH2:19]2)[CH2:12]1

Participants

3

Reactant 2

HCID 97998(1-Methyl-3-piperidyl)methanolHCID 1317286034-Isobutoxy-1h-indole-2-carboxylic acid [1-(octahydro-quinolizin-1-ylmethyl)-piperidin-4-yl]-amide dihydrochloride

Product 1

HCID 596001234-Isobutoxy-1H-indole-2-carboxylic acid [1-(1-methyl-piperidin-3-ylmethyl)-piperidin-4-yl]-amide

Procedure

This compound is synthesized from the compound 161 (see example 127) and (1-Methyl-piperidin-3-yl)-methanol analogously to the method described in Example 127.

Sources & evidence

ORD record
ord-f7e2e65ed20241e49cd8ad6eb88ea50a
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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