Hydrochloric Acid → 2-(4-Aminopiperidin-1-yl)ethan-1-ol

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	1,4-Dioxane	HCID 31275	—
Reactant	[1-(2-Hydroxy-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester	HCID 45076484	—
Product	2-(4-Aminopiperidin-1-yl)ethan-1-ol	HCID 15733445	—

Reaction Steps

Compound 191 (4.02 g, 16.46 mmol) are treated with 4M HCl in dioxane (60 ml, 240 mmol) and the mixture is stirred at room temperature for 1 h. The white precipitate is filtered off, washed with ether and dried under high vacuum. The mother liquor is concentrated and treatred with ether. The white solid is filtered off and dried under high vacuum.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07858781B2
Source dataset	uspto-grants-2010_12
ORD ID	ord-cb75212c886b49b6bd324669d622a907
Source note	uspto-grants-2010_12