Hydrochloric Acid → 2-(4-Aminopiperidin-1-yl)ethan-1-ol

HRID 2267926Notes

Reaction equation

HRID 2267926 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][OH:16])[CH2:10][CH2:9]1)(C)(C)C.Cl.O1CCOCC1>>[NH2:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][OH:16])[CH2:10][CH2:9]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 45076484[1-(2-Hydroxy-ethyl)-piperidin-4-yl]-carbamic acid tert-butyl ester

Product 1

HCID 157334452-(4-Aminopiperidin-1-yl)ethan-1-ol

Procedure

Compound 191 (4.02 g, 16.46 mmol) are treated with 4M HCl in dioxane (60 ml, 240 mmol) and the mixture is stirred at room temperature for 1 h. The white precipitate is filtered off, washed with ether and dried under high vacuum. The mother liquor is concentrated and treatred with ether. The white solid is filtered off and dried under high vacuum.

Workup

  1. filtrationThe white precipitate is filtered off
  2. washwashed with ether
  3. customdried under high vacuum
  4. concentrationThe mother liquor is concentrated
  5. filtrationThe white solid is filtered off
  6. customdried under high vacuum

Sources & evidence

ORD record
ord-cb75212c886b49b6bd324669d622a907
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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