Piperidine → 4-(5-Chloro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid [4-(2-piperidin-1-yl-ethyl)-phenyl]-amide

HRID 2267931Notes

Reaction equation

HRID 2267931 reaction equation
O[CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([C:13]2[NH:14][C:15]3[C:20]([CH:21]=2)=[C:19]([O:22][CH2:23][C:24]2[C:28]4[CH:29]=[C:30]([Cl:33])[CH:31]=[CH:32][C:27]=4[O:26][CH:25]=2)[CH:18]=[CH:17][CH:16]=3)=[O:12])=[CH:6][CH:5]=1.[NH:34]1[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]1>>[N:34]1([CH2:2][CH2:3][C:4]2[CH:9]=[CH:8][C:7]([NH:10][C:11]([C:13]3[NH:14][C:15]4[C:20]([CH:21]=3)=[C:19]([O:22][CH2:23][C:24]3[C:28]5[CH:29]=[C:30]([Cl:33])[CH:31]=[CH:32][C:27]=5[O:26][CH:25]=3)[CH:18]=[CH:17][CH:16]=4)=[O:12])=[CH:6][CH:5]=2)[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]1

Participants

3

Reactant 2

HCID 8082PiperidineHCID 66841637HCID 66841637, compound

Product 1

HCID 596002184-(5-Chloro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid [4-(2-piperidin-1-yl-ethyl)-phenyl]-amide

Procedure

This compound is synthesized analogously to example 150 from 4-(5-Chloro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid [4-(2-hydroxy-ethyl)-phenyl]-amide (193, preparation see below) and piperidine.

Sources & evidence

ORD record
ord-249dde58e32e43aeb9d3a7e2d7d065cd
Source dataset
uspto-grants-2010_12
Patent number
US07858781B2

Reaction notes

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