HRID2267933

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID57464983

未命名化合物

结构：O=C(Nc1ccc(CCO)cc1)c1cc2c(OCc3coc4ccc(Cl)cc34)cccc2[nH]1

HCID66841637

未命名化合物

PRODUCTS

生成物

结构：O=C(Nc1ccc(CCN2CCC(O)CC2)cc1)c1cc2c(OCc3coc4ccc(Cl)cc34)cccc2[nH]1

HCID59600144

未命名化合物

PROCEDURE

实验过程

This compound is synthesized analogously to example 154 from 4-(5-Chloro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid [4-(2-hydroxy-ethyl)-phenyl]-amide (193) and 2,2-dimethyl-propionic acid piperidin-4-yl ester, followed by removal of the protective group by sodium methylate.

WORKUP

后处理

customfollowed by removal of the protective group by sodium methylate

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c995516de0594922961d08c8387f37f5
来源数据集: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07858781B2
来源说明: uspto-grants-2010_12

反应 SMILES

O[CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]([C:13]2[NH:14][C:15]3[C:20]([CH:21]=2)=[C:19]([O:22][CH2:23][C:24]2[C:28]4[CH:29]=[C:30]([Cl:33])[CH:31]=[CH:32][C:27]=4[O:26][CH:25]=2)[CH:18]=[CH:17][CH:16]=3)=[O:12])=[CH:6][CH:5]=1.[NH:34]1[CH2:39][CH2:38][CH:37]([O:40]C(=O)C(C)(C)C)[CH2:36][CH2:35]1>>[OH:40][CH:37]1[CH2:36][CH2:35][N:34]([CH2:2][CH2:3][C:4]2[CH:5]=[CH:6][C:7]([NH:10][C:11]([C:13]3[NH:14][C:15]4[C:20]([CH:21]=3)=[C:19]([O:22][CH2:23][C:24]3[C:28]5[CH:29]=[C:30]([Cl:33])[CH:31]=[CH:32][C:27]=5[O:26][CH:25]=3)[CH:18]=[CH:17][CH:16]=4)=[O:12])=[CH:8][CH:9]=2)[CH2:39][CH2:38]1