HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidin-4-yl pivalate → 4-(5-Chloro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {4-[2-(4-hydroxy-piperidin-1-yl)-ethyl]-phenyl}-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidin-4-yl pivalate | HCID 57464983 | — |
| Reactant | HCID 66841637 | HCID 66841637 | — |
| Product | 4-(5-Chloro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid {4-[2-(4-hydroxy-piperidin-1-yl)-ethyl]-phenyl}-amide | HCID 59600144 | — |
Reaction Steps
This compound is synthesized analogously to example 154 from 4-(5-Chloro-benzofuran-3-ylmethoxy)-1H-indole-2-carboxylic acid [4-(2-hydroxy-ethyl)-phenyl]-amide (193) and 2,2-dimethyl-propionic acid piperidin-4-yl ester, followed by removal of the protective group by sodium methylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07858781B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-c995516de0594922961d08c8387f37f5 |
| Source note | uspto-grants-2010_12 |