HRID2267943

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2734368

2-Methoxy-5-pyridineboronic acid

C6H8BNO3

结构：O=C(NC1CCN(CCN2C3CCC2CC(O)C3)CC1)c1cc2c(Br)cccc2[nH]1

HCID66841447

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(-c2cccc3[nH]c(C(=O)NC4CCN(CCN5C6CCC5CC(O)C6)CC4)cc23)cn1

HCID59600164

未命名化合物

PROCEDURE

实验过程

This compound is synthesized from compound 197 (see example 175) and (6-methoxy-pyridin-3-yl)-boronic acid analogously to the method described in Example 156.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3a3c095eccf7401f80b1c407d8a9e644
来源数据集: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07858781B2
来源说明: uspto-grants-2010_12

反应 SMILES

[OH:1][CH:2]1[CH2:8][CH:7]2[N:9]([CH2:10][CH2:11][N:12]3[CH2:17][CH2:16][CH:15]([NH:18][C:19]([C:21]4[NH:22][C:23]5[C:28]([CH:29]=4)=[C:27](Br)[CH:26]=[CH:25][CH:24]=5)=[O:20])[CH2:14][CH2:13]3)[CH:4]([CH2:5][CH2:6]2)[CH2:3]1.[CH3:31][O:32][C:33]1[N:38]=[CH:37][C:36](B(O)O)=[CH:35][CH:34]=1>>[OH:1][CH:2]1[CH2:8][CH:7]2[N:9]([CH2:10][CH2:11][N:12]3[CH2:17][CH2:16][CH:15]([NH:18][C:19]([C:21]4[NH:22][C:23]5[C:28]([CH:29]=4)=[C:27]([C:36]4[CH:37]=[N:38][C:33]([O:32][CH3:31])=[CH:34][CH:35]=4)[CH:26]=[CH:25][CH:24]=5)=[O:20])[CH2:14][CH2:13]3)[CH:4]([CH2:5][CH2:6]2)[CH2:3]1