(6-Methoxypyridin-3-yl)boronic acid → 4-(6-Methoxy-pyridin-3-yl)-1H-indole-2-carboxylic acid {1-[2-(3-hydroxy-8-aza-bicyclo[3.2.1]oct-8-yl)-ethyl]-piperidin-4-yl}-amide

Participants

Role	Name	HCID	Charge
Reactant	(6-Methoxypyridin-3-yl)boronic acid	HCID 2734368	—
Reactant	4-Bromo-1H-indole-2-carboxylic acid {1-[2-(3-hydroxy-8-aza-bicyclo[3.2.1]oct-8-yl)-ethyl]-piperidin-4-yl}-amide	HCID 66841447	—
Product	4-(6-Methoxy-pyridin-3-yl)-1H-indole-2-carboxylic acid {1-[2-(3-hydroxy-8-aza-bicyclo[3.2.1]oct-8-yl)-ethyl]-piperidin-4-yl}-amide	HCID 59600164	—

Reaction Steps

This compound is synthesized from compound 197 (see example 175) and (6-methoxy-pyridin-3-yl)-boronic acid analogously to the method described in Example 156.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07858781B2
Source dataset	uspto-grants-2010_12
ORD ID	ord-3a3c095eccf7401f80b1c407d8a9e644
Source note	uspto-grants-2010_12