Sodium Hydroxide → HCID 73431542, compound

HRID 2268022Notes

Reaction equation

HRID 2268022 reaction equation
[C:1]([CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:16][OH:17].[OH-].[Na+]>C(O)C>[N:16](=[C:1]([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH2:9][CH2:10][CH2:11][C:12]([OH:14])=[O:13])[OH:17]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 73914delta-Oxobenzenepentanoic acidHCID 443297Hydroxyamine hydrochloride

Product 1

HCID 73431542HCID 73431542, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
120 °C

Procedure

4-benzoylbutyric acid (4.26 g, 22.2 mmol), a 5 mL solution of aqueous hydroxylamine hydrochloride (1.80 g, 25.9 mmol), and a 2.0M solution of aqueous sodium hydroxide (14 mL, 28.0 mmol) were combined in 15 mL of absolute ethanol. The mixture was refluxed at 120° C. for 1 hour, then evaporated in vacuo to remove ethanol. A few drops of a 2.0M solution of aqueous hydrochloric acid were added to the solution to achieve a pH of 6. Then more water was added, and the slurry was filtered to isolate the title compound as a solid.

Workup

  1. customevaporated in vacuo
  2. customto remove ethanol
  3. additionA few drops of a 2.0M solution of aqueous hydrochloric acid were added to the solution
  4. additionThen more water was added
  5. filtrationthe slurry was filtered

Sources & evidence

ORD record
ord-5e2e21a907204585ae737bde322cc935
Source dataset
uspto-grants-2001_12
Patent number
US06326372B1

Reaction notes

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