Tetrahydrofuran → HCID 66647628, compound

HRID 2268138Notes

Reaction equation

HRID 2268138 reaction equation
CO[C:3]1[C:4](=O)[NH:5][CH:6]=[CH:7][CH:8]=1.Cl.Cl.[CH:12]1([NH:17][NH2:18])CCCC1.[O:19]1CCCC1>>[N:18]1[C:3]2[CH:8]=[CH:7][CH:6]=[N:5][C:4]=2[C:12](=[O:19])[N:17]=1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 887313-Methoxy-2-pyridoneHCID 18349526Cyclopentylhydrazinato--hydrogen chlorido (1/2)

Product 1

HCID 66647628HCID 66647628, compound

Conditions

Temperature
88 °C

Procedure

treating said 3-methoxy-pyridinone compound of Formula (7.0.0) with cyclopentylhydrazine dihydrochioride; wherein a reaction mixture is established with tetrahydrofuran (THF) solvent and heating of said reaction mixture to 88° C., for 12 hours, while said reaction mixture is being swept by nitrogen in order to remove methanol, THF, and HCl; whereby there is produced a pyrazolopyridinone compound N-protected by p-methoxybenzyl, of Formula (8.0.0):

Workup

  1. additiontreating
  2. customreaction mixture
  3. customto remove methanol, THF, and HCl

Sources & evidence

ORD record
ord-1d7f7bb51af94a55aaa0def4df02b40a
Source dataset
uspto-grants-2001_12
Patent number
US06326495B2

Reaction notes

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