Triethyloxonium tetrafluoroborate → 1H-PYRAZOLO[3,4-C]PYRIDINE, 1-CYCLOPENTYL-7-ETHOXY-3-ETHYL-4,5-DIHYDRO-

HRID 2268149Notes

Reaction equation

HRID 2268149 reaction equation
[CH:1]1([N:6]2[C:10]3[C:11](=[O:15])[NH:12][CH2:13][CH2:14][C:9]=3[C:8]([CH2:16][CH3:17])=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.F[B-](F)(F)F.[CH2:23]([O+](CC)CC)[CH3:24]>C(Cl)Cl>[CH:1]1([N:6]2[C:10]3[C:11]([O:15][CH2:23][CH3:24])=[N:12][CH2:13][CH2:14][C:9]=3[C:8]([CH2:16][CH3:17])=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 2723982Triethyloxonium tetrafluoroborate2×HCID 108235421-Cyclopentyl-3-ethyl-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one2×

Product 1

HCID 98457511H-PYRAZOLO[3,4-C]PYRIDINE, 1-CYCLOPENTYL-7-ETHOXY-3-ETHYL-4,5-DIHYDRO-

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

esterifying said lactam compound of Formula (9.0.0) using triethyloxonium tetrafluoroborate, (CH3CH2)2OBF4; wherein a reaction mixture is established by slowly adding a solution of triethyloxonium tetrafluoroborate, (CH3CH2)3OBF4 in methylene chloride to a suspension of said lactam compound of Formula (9.0.0) in methylene chloride over a period of 40 minutes; and thereafter, maintaining said reaction mixture at a temperature of from 18° to 22° C., for a period of 21 hours; whereby there is produced a corresponding imino ester (imidate) compound of Formula (10.0.0):

Workup

  1. temperatureand thereafter, maintaining
  2. customreaction mixture at a temperature of from 18° to 22° C.

Sources & evidence

ORD record
ord-4c211279218b471ca5b8a8f55e4ad5b4
Source dataset
uspto-grants-2001_12
Patent number
US06326495B2

Reaction notes

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