Pyridine → HCID 10058448, compound

HRID 2268184Notes

Reaction equation

HRID 2268184 reaction equation
C1(CN2CCC(C[CH2:15][C:16]3[C:20]4[CH:21]=[C:22]5[NH:27][C:26](=[O:28])[CH2:25][C:23]5=[CH:24][C:19]=4[O:18][N:17]=3)CC2)C=CC=CC=1.N1C=CC=CC=1>CN(C=O)C>[CH3:15][C:16]1[C:20]2[CH:21]=[C:22]3[NH:27][C:26](=[O:28])[CH2:25][C:23]3=[CH:24][C:19]=2[O:18][N:17]=1

Participants

4

Reactant 2

HCID 1049PyridineHCID 9976761HCID 9976761, compound

Product 1

HCID 10058448HCID 10058448, compoundYield 12%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The procedure described in Example 33d was followed with the oxime acetate obtained in step c (2.75 g, 10.97 mmol) and pyridine (8.9 mL, 109.7 mmol) in DMF (110 m). After concentration in vacuo, the residue was purified by silica gel flash chromatography (2% MeOH—CH2Cl2) to give the title compound (0.245 g, 12%) as a pastel yellow solid.

Workup

  1. concentrationAfter concentration in vacuo
  2. customthe residue was purified by silica gel flash chromatography (2% MeOH—CH2Cl2)

Sources & evidence

ORD record
ord-fd6da3edc5f44e648da90b86e5a53466
Source dataset
uspto-grants-2001_12
Patent number
US06326382B1

Reaction notes

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