Methyl 4-aminobenzoate → Methyl 4-[3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)acryloylamino]benzoate

HRID 2268205Notes

Reaction equation

HRID 2268205 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][CH:3]=1.[CH3:12][C:13]1([CH3:30])[CH2:22][CH2:21][C:20]([CH3:24])([CH3:23])[C:19]2[CH:18]=[C:17]([CH:25]=[CH:26][C:27](Cl)=[O:28])[CH:16]=[CH:15][C:14]1=2>>[CH3:12][C:13]1([CH3:30])[CH2:22][CH2:21][C:20]([CH3:23])([CH3:24])[C:19]2[CH:18]=[C:17]([CH:25]=[CH:26][C:27]([NH:1][C:2]3[CH:3]=[CH:4][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:10][CH:11]=3)=[O:28])[CH:16]=[CH:15][C:14]1=2

Participants

3

Reactant 2

HCID 12082Methyl 4-aminobenzoateHCID 734315563-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)acryloyl chloride

Product 1

HCID 70214611Methyl 4-[3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)acryloylamino]benzoate

Procedure

In a similar manner to that of Example 1(d), by reaction of 1.5 g (10 mmol) of methyl 4-amino-benzoate with 2.8 g (10 mmol) of 3-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)acryloyl chloride, 3.2 g (82%) of the expected methyl ester are obtained.

Workup

  1. customare obtained

Sources & evidence

ORD record
ord-eb9e98d0e30a47f78b987a0381e84a2a
Source dataset
uspto-grants-2001_12
Patent number
US06326510B1

Reaction notes

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