Dichloromethane → HCID 18349602, compound

Participants

Reaction Steps

A solution of 5-chlorovaleryl chloride (3.76 g) in dichloromethane (8 ml) was added dropwise with stirring to a mixture of 1-methyl-(1-phenoxymethyl)ethylamine (4.0 g) and triethylamine (2.9 g) in dichloromethane (30 ml) whilst keeping the temperature below 0° C. After the addition the reaction mixture was allowed to warm to ambient temperature and then stirred at that temperature for 2 hours. The mixture was worked up in a similar manner to Example 55 to give 5-chloro-N-(1,1-dimethyl-2-phenoxyethyl)valeramide as an oil.

Provenance & Evidence