Dichloromethane → HCID 18349602, compound

HRID 2268249Notes

Reaction equation

HRID 2268249 reaction equation
[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6](Cl)=[O:7].CC(N[CH2:13][O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)C.C([N:23]([CH2:26][CH3:27])CC)C.Cl[CH2:29]Cl>>[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]([NH:23][C:26]([CH3:27])([CH3:29])[CH2:13][O:14][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)=[O:7]

Participants

5

Reactant 4

HCID 6344Dichloromethane2×HCID 8471TriethylamineHCID 740895-Chlorovaleryl chlorideHCID 53665207HCID 53665207, compound

Product 1

HCID 18349602HCID 18349602, compound

Procedure

A solution of 5-chlorovaleryl chloride (3.76 g) in dichloromethane (8 ml) was added dropwise with stirring to a mixture of 1-methyl-(1-phenoxymethyl)ethylamine (4.0 g) and triethylamine (2.9 g) in dichloromethane (30 ml) whilst keeping the temperature below 0° C. After the addition the reaction mixture was allowed to warm to ambient temperature and then stirred at that temperature for 2 hours. The mixture was worked up in a similar manner to Example 55 to give 5-chloro-N-(1,1-dimethyl-2-phenoxyethyl)valeramide as an oil.

Workup

  1. customthe temperature below 0° C
  2. additionAfter the addition the reaction mixture

Sources & evidence

ORD record
ord-a08515e3786a4de9a7e980072ef40314
Source dataset
uspto-grants-2001_12
Patent number
US06326500B1

Reaction notes

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