4-Cyanobenzenesulfonyl chloride → HCID 18349605, compound

HRID 2268271Notes

Reaction equation

HRID 2268271 reaction equation
[NH2:1][C:2]([C:5]1[CH:13]=[CH:12][C:8]([CH2:9][CH2:10][NH2:11])=[CH:7][CH:6]=1)([CH3:4])[CH3:3].[C:14]([C:16]1[CH:21]=[CH:20][C:19]([S:22](Cl)(=[O:24])=[O:23])=[CH:18][CH:17]=1)#[N:15]>ClCCl.C(N(CC)CC)C>[NH2:1][C:2]([C:5]1[CH:13]=[CH:12][C:8]([CH2:9][CH2:10][NH:11][S:22]([C:19]2[CH:18]=[CH:17][C:16]([C:14]#[N:15])=[CH:21][CH:20]=2)(=[O:24])=[O:23])=[CH:7][CH:6]=1)([CH3:4])[CH3:3]

Participants

5

Reactant 2

HCID 394974-Cyanobenzenesulfonyl chlorideHCID 183495674-(1-Amino-1-methylethyl)benzeneethanamine

Product 1

HCID 18349605HCID 18349605, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8471TriethylamineSolvent

Procedure

4-(1-Amino-1-methylethyl)phenethylamine (A18, 2.132 g) was treated with 4-cyanophenylsulphonyl chloride (2.63 g) in dichloromethane (35 ml) and triethylamine (1.8 ml) to give N-{2-[4-(1-amino-1-methylethyl)phenyl]ethyl}-4-cyanobenzenesulphonamide, as an oil.

Sources & evidence

ORD record
ord-1233f79f31ef4670b8ef562c784d8db0
Source dataset
uspto-grants-2001_12
Patent number
US06326500B1

Reaction notes

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