HCID 22644926, compound → HCID 86757633, compound

HRID 2268289Notes

Reaction equation

HRID 2268289 reaction equation
[CH2:1]([O:5][C:6]1[CH:11]=[CH:10][C:9]([S:12]([NH:15][C:16]2([C:21](O)=O)[CH2:20][CH2:19][CH2:18][CH2:17]2)(=[O:14])=[O:13])=[CH:8][CH:7]=1)[C:2]#[C:3][CH3:4].C(OC1C=CC(S(N[C@H]2CCC[C@H]2[C:44]([NH:46][OH:47])=[O:45])(=O)=O)=CC=1)C#CC>>[CH2:1]([O:5][C:6]1[CH:7]=[CH:8][C:9]([S:12]([NH:15][C@H:16]2[CH2:20][CH2:19][CH2:18][CH2:17][C@H:21]2[C:44]([NH:46][OH:47])=[O:45])(=[O:13])=[O:14])=[CH:10][CH:11]=1)[C:2]#[C:3][CH3:4]

Participants

3

Reactant 2

HCID 22644926HCID 22644926, compoundHCID 86757634HCID 86757634, compound

Product 1

HCID 86757633HCID 86757633, compoundYield 63.5%

Procedure

(1R,2S)-2-[{[4-(2-Butynyloxy)phenyl]sulfonyl}aminocyclopentanecarboxylic acid (0.506 g, 1.5 mmol) was converted to (1R, 2S)-2-[{[4-(2-butynyloxy)phenyl]sulfonyl}amino)-N-hydroxycyclopentanecarboxamide (0.28 g) as described in Example 21 to give an off-white solid (0.185 g), mp 140-145° C. Electrospray Mass Spec 353.4 (M+H)+.

Sources & evidence

ORD record
ord-3a5661ef03b64648bbf2fc24b1d54446
Source dataset
uspto-grants-2001_12
Patent number
US06326516B1

Reaction notes

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