HCID 59975285, compound → HCID 59975296, compound

HRID 2268358Notes

Reaction equation

HRID 2268358 reaction equation
[OH:1][C@@H:2]1[C@H:6]([OH:7])[C@@H:5]([CH2:8][O:9][CH3:10])[O:4][C@H:3]1[N:11]1[CH:19]=[N:18][C:17]2[C:12]1=[N:13][C:14]([CH2:35][NH:36][S:37]([C:40]1[CH:45]=[CH:44][C:43]([CH:46]3[CH2:51][CH2:50][N:49](C(=O)C(F)(F)F)[CH2:48][CH2:47]3)=[CH:42][CH:41]=1)(=[O:39])=[O:38])=[N:15][C:16]=2[NH:20][CH2:21][CH:22]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>N>[OH:1][C@@H:2]1[C@H:6]([OH:7])[C@@H:5]([CH2:8][O:9][CH3:10])[O:4][C@H:3]1[N:11]1[CH:19]=[N:18][C:17]2[C:12]1=[N:13][C:14]([CH2:35][NH:36][S:37]([C:40]1[CH:45]=[CH:44][C:43]([CH:46]3[CH2:47][CH2:48][NH:49][CH2:50][CH2:51]3)=[CH:42][CH:41]=1)(=[O:38])=[O:39])=[N:15][C:16]=2[NH:20][CH2:21][CH:22]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Participants

3

Reactant 1

HCID 59975285HCID 59975285, compound

Product 1

HCID 59975296HCID 59975296, compoundYield 78.8%

Reagents, catalysts & solvents 1

HCID 222AmmoniaSolvent

Procedure

The title compound was prepared by a similar method to example 20 using N-({9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(methoxymethyl)tetrahydro-2-furanyl]-6-[(2,2-diphenylethyl)amino]-9H-purin-2-yl}methyl)-4-[1-(2,2,2-trfluoroacetyl)-4-piperidinyl]benzenesulfonamide (0.26 g, 0.32 mmol) (example 21) and a saturated methanolic solution of ammonia (20 ml). This gave the title compound (180 mg) as a solid. MS: 715 (MH+)

Sources & evidence

ORD record
ord-bf93511599634a0da4ded4f08460fdaa
Source dataset
uspto-grants-2001_12
Patent number
US06326359B1

Reaction notes

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