Hydrochloric Acid → HCID 178419062, compound

Participants

Reaction Steps

A stirred solution of 6-[(2,2-diphenylethyl)amino]-9-tetrahydro-2H-pyran-2-yl-9H-purine-2-carbonitrile (preparation 9) (17 g, 40.1 mmol) in ethanol (850 ml), was treated with 2 molar hydrochloric acid (50 ml) and the mixture stirred at room temperature for 24 hr. The solvent was then removed under reduced pressure, the residue dissolved in ethanol and the solvent removed under reduced pressure (repeated). The residue was triturated with diethyl ether, the mixture filtered and the collected material washed with diethyl ether and pentane, then dried to afford the title compound as a solid (14.3 g). MS: 341 (MH+)

Provenance & Evidence