Hydrochloric Acid → HCID 178419062, compound

HRID 2268408Notes

Reaction equation

HRID 2268408 reaction equation
[C:1]1([CH:7]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:8][NH:9][C:10]2[N:18]=[C:17]([C:19]#[N:20])[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][N:14]3C2CCCCO2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl>C(O)C>[C:27]1([CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:8][NH:9][C:10]2[N:18]=[C:17]([C:19]#[N:20])[N:16]=[C:15]3[C:11]=2[N:12]=[CH:13][NH:14]3)[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 101593916-((2,2-Diphenylethyl)amino)-9-(tetrahydro-2H-pyran-2-yl)-9H-purine-2-carbonitrile

Product 1

HCID 178419062HCID 178419062, compoundYield 104.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A stirred solution of 6-[(2,2-diphenylethyl)amino]-9-tetrahydro-2H-pyran-2-yl-9H-purine-2-carbonitrile (preparation 9) (17 g, 40.1 mmol) in ethanol (850 ml), was treated with 2 molar hydrochloric acid (50 ml) and the mixture stirred at room temperature for 24 hr. The solvent was then removed under reduced pressure, the residue dissolved in ethanol and the solvent removed under reduced pressure (repeated). The residue was triturated with diethyl ether, the mixture filtered and the collected material washed with diethyl ether and pentane, then dried to afford the title compound as a solid (14.3 g). MS: 341 (MH+)

Workup

  1. customThe solvent was then removed under reduced pressure
  2. dissolutionthe residue dissolved in ethanol
  3. customthe solvent removed under reduced pressure (repeated)
  4. customThe residue was triturated with diethyl ether
  5. filtrationthe mixture filtered
  6. washthe collected material washed with diethyl ether and pentane
  7. customdried

Sources & evidence

ORD record
ord-4d456df98f584e77b86d56c3ce3dccda
Source dataset
uspto-grants-2001_12
Patent number
US06326359B1

Reaction notes

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