反应详情

A stirred solution of tert-butyl trans-4-[(methylsulfonyl)amino]cyclohexylcarbamate (990 mg, 3.39 mmol) (preparation 32) in dichloromethane (25 ml) at room temperature was saturated with hydrogen chloride gas. The reaction mixture was stirred at room temperature for 2 hr and the solvent then removed under reduced pressure to give a colourless solid. The solid was triturated with diethyl ether and then suspended in ethyl acetate and exposed to ultrasonic agitation for 5 min. The remaining solid was filtered off to give the title compound (0.6 g) as a solid.

1. customat room temperature
2. customthe solvent then removed under reduced pressure
3. customto give a colourless solid
4. customThe solid was triturated with diethyl ether
5. waitexposed to ultrasonic agitation for 5 min
6. filtrationThe remaining solid was filtered off