Hydrochloric Acid → HCID 178510600, compound

HRID 2268430Notes

Reaction equation

HRID 2268430 reaction equation
Cl.[CH2:2]([NH:10][C:11]1[N:19]=[C:18]([C:20]#[N:21])[N:17]=[C:16]2[C:12]=1[N:13]=[CH:14][N:15]2C1CCCCO1)[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>C(O)C>[CH2:2]([NH:10][C:11]1[N:19]=[C:18]([C:20]#[N:21])[N:17]=[C:16]2[C:12]=1[N:13]=[CH:14][NH:15]2)[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 207091976-(Phenethylamino)-9-tetrahydro-2H-pyran-2-yl-9H-purine-2-carbonitrile

Product 1

HCID 178510600HCID 178510600, compoundYield 83.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2 Molar hydrochloric acid (10 ml) was added to a stirred solution of 6-(phenethylamino)-9-tetrahydro-2H-pyran-2-yl-9H-purine-2-carbonitrile (10.2 g, 27.6 mmol) (preparation 44) in ethanol (250 ml) at 60° C. The solution was allowed to cool to room temperature and the white solid that had been formed filtered off. After drying, this gave the title compound (6.1 g) as a white crystalline solid. MS: 265 (MH+).

Workup

  1. customthe white solid that had been formed
  2. filtrationfiltered off
  3. customAfter drying

Sources & evidence

ORD record
ord-b985a8a18f78421398056a2e312e425d
Source dataset
uspto-grants-2001_12
Patent number
US06326359B1

Reaction notes

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