HCID 18348527, compound → HCID 18348610, compound

HRID 2268451Notes

Reaction equation

HRID 2268451 reaction equation
[CH3:1][O:2][C:3]1[C:11]([O:12][CH3:13])=[C:10]([O:14][CH3:15])[C:9]([O:16][CH3:17])=[C:8]2[C:4]=1[CH:5]=[C:6]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])[CH2:7]2>[C].[Pd].C(O)C>[CH3:17][O:16][C:9]1[C:10]([O:14][CH3:15])=[C:11]([O:12][CH3:13])[C:3]([O:2][CH3:1])=[C:4]2[C:8]=1[CH2:7][CH:6]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])[CH2:5]2

Participants

4

Reactant 1

HCID 18348527HCID 18348527, compound

Product 1

HCID 18348610HCID 18348610, compoundYield 99.5%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

An ethanol (6.0 ml) suspension of ethyl 8-(4,5,6,7-tetramethoxyinden-2-yl)octanoate (310 mg, 0.763 mmols)and 10% palladium-carbon (60 mg) was stirred under a hydrogen atmosphere at room temperature for 4 hours. The palladium-carbon was removed by filtration, and the filtrate was concentrated in vacuo to obtain the entitled compound (310 mg) as an oil.

Workup

  1. customThe palladium-carbon was removed by filtration
  2. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-646416b4118c44639580e44fdaa6342d
Source dataset
uspto-grants-2001_12
Patent number
US06326369B1

Reaction notes

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