反应详情

Lithium aluminium hydride (41.8 mg, 1.10 mmols) was added to a diethyl ether (3.0 ml) solution of ethyl 8-(4,5,6,7-tetramethoxyindan-2-yl)octanoate (150 mg, 367 mmols), with cooling with ice. The reaction mixture was allowed to warm to room temperature and stirred for 1 hour. 1 N hydrochloric acid was added to the reaction mixture, which was then extracted with ethyl acetate. The organic layer was washed with water and a saturated aqueous sodium chloride solution, and then dried. The solvent was evaporated out in vacuo, and the resulting crude product was purified by silica gel column chromatography (hexane:ethyl acetate=10:1 to 4:1) to obtain the entitled compound (138 mg) as an oil.

1. temperaturewith cooling with ice
2. extractionwas then extracted with ethyl acetate
3. washThe organic layer was washed with water
4. dry with materiala saturated aqueous sodium chloride solution, and then dried
5. customThe solvent was evaporated out in vacuo
6. customthe resulting crude product was purified by silica gel column chromatography (hexane:ethyl acetate=10:1 to 4:1)