反应详情

An aqueous sodium hydroxide solution (3 N, 0.204 ml, 0.612 mmols) was added to an ethanol (4 ml) solution of ethyl 2-(4-benzyloxyphenyl)-4,5,6,7-tetramethoxy-2-indancarboxylate (150 mg, 0.305 mmols), and heated under reflux for 6 hours. The reaction mixture was concentrated in vacuo, and was made acidic by adding 1 N hydrochloric acid and then extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, and then dried. The solvent was evaporated out in vacuo, and the resulting crude product was purified by recrystallization (from hexane-ethyl acetate) to obtain the entitled compound (108 mg) as crystals.

1. temperatureheated
2. temperatureunder reflux for 6 hours
3. concentrationThe reaction mixture was concentrated in vacuo
4. additionby adding 1 N hydrochloric acid
5. extractionextracted with ethyl acetate
6. washThe organic layer was washed with a saturated aqueous sodium chloride solution
7. customdried
8. customThe solvent was evaporated out in vacuo
9. customthe resulting crude product was purified by recrystallization (from hexane-ethyl acetate)