Sodium Hydroxide → 2-(4-Benzyloxyphenyl)-4,5,6,7-tetramethoxy-2-indancarboxylic acid

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Reaction Steps

An aqueous sodium hydroxide solution (3 N, 0.204 ml, 0.612 mmols) was added to an ethanol (4 ml) solution of ethyl 2-(4-benzyloxyphenyl)-4,5,6,7-tetramethoxy-2-indancarboxylate (150 mg, 0.305 mmols), and heated under reflux for 6 hours. The reaction mixture was concentrated in vacuo, and was made acidic by adding 1 N hydrochloric acid and then extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, and then dried. The solvent was evaporated out in vacuo, and the resulting crude product was purified by recrystallization (from hexane-ethyl acetate) to obtain the entitled compound (108 mg) as crystals.

Provenance & Evidence