反应详情

温度

40 °C

To a solution of 8-(4,5,6,7-tetramethoxyindan-2-yl)octanol (1.20 g) and ethyl isocyanate (0.517 ml) in THF (12 ml) was added one drop of pyridine. After being stirred for 12 hr at 40° C., the reaction mixture was concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=2:1) to yield the entitled compound (1.42 g) as crystals.

1. concentrationthe reaction mixture was concentrated in vacuo
2. customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=2:1)