Trifluoroacetic acid → HCID 18349093, compound

HRID 2268641Notes

Reaction equation

HRID 2268641 reaction equation
C(OC(=O)[N:7]([CH2:14][CH2:15][O:16][C:17]1[CH:22]=[C:21]([Cl:23])[CH:20]=[C:19]([C:24](=[O:36])[N:25]([CH2:31][CH2:32][C:33](=[O:35])[NH2:34])[CH:26]2[CH2:30][CH2:29][CH2:28][CH2:27]2)[CH:18]=1)[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)(C)(C)C.[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41]>ClCCl>[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41].[C:33]([CH2:32][CH2:31][N:25]([CH:26]1[CH2:30][CH2:29][CH2:28][CH2:27]1)[C:24](=[O:36])[C:19]1[CH:18]=[C:17]([O:16][CH2:15][CH2:14][NH:7][C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)[CH:22]=[C:21]([Cl:23])[CH:20]=1)(=[O:35])[NH2:34]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 53884199HCID 53884199, compound

Product 1

HCID 18349093HCID 18349093, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of (2-{3-[(2-carbamoyl-ethyl)-cyclopentyl-carbamoyl]-5-chloro-phenoxy}-ethyl)-pyridin-4-yl-carbamic acid tert-butyl ester (0.074 g) in a mixture of dichloromethane (1 ml) and trifluoroacetic acid (1 ml) was stored at room temperature for 2 h and then concentrated under reduced pressure to give the title compound (0.060 g) as a colourless gum.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-4eb40ea14c32480d8c3cb545b2ccb20d
Source dataset
uspto-grants-2001_12
Patent number
US06326386B1

Reaction notes

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