Trifluoroacetic acid → HCID 18349221, compound

HRID 2268642Notes

Reaction equation

HRID 2268642 reaction equation
C(OC(=O)[N:7]([CH2:14][CH2:15][O:16][C:17]1[CH:22]=[C:21]([C:23](=[O:32])[N:24]([CH2:28][CH2:29][C:30]#[N:31])[CH:25]2[CH2:27][CH2:26]2)[CH:20]=[C:19]([Cl:33])[CH:18]=1)[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)(C)(C)C.FC(F)(F)C(O)=[O:38]>ClCCl>[ClH:33].[C:30]([CH2:29][CH2:28][N:24]([CH:25]1[CH2:26][CH2:27]1)[C:23](=[O:32])[C:21]1[CH:22]=[C:17]([O:16][CH2:15][CH2:14][NH:7][C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)[CH:18]=[C:19]([Cl:33])[CH:20]=1)(=[O:38])[NH2:31]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 54452444HCID 54452444, compound

Product 1

HCID 18349221HCID 18349221, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of (2-{3-chloro-5-[(2-cyano-ethyl)-cyclopropyl-carbamoyl]-phenoxy}-ethyl)-pyridin-4-yl-carbamic acid tert-butyl ester (0.075 g) in a mixture of dichloromethane (5 ml) and trifluoroacetic acid (5 ml) was stored at room temperature for 18 h and then concentrated under reduced pressure. The residue was triturated with ethereal hydrogen chloride to give the title compound (0.065 g) as a colourless gum.

Workup

  1. concentrationconcentrated under reduced pressure
  2. customThe residue was triturated with ethereal hydrogen chloride

Sources & evidence

ORD record
ord-02072aeb496043959d4fd4c5e0f5eb77
Source dataset
uspto-grants-2001_12
Patent number
US06326386B1

Reaction notes

Loading…