HCID 53845544, compound → HCID 18349043, compound

HRID 2268643Notes

Reaction equation

HRID 2268643 reaction equation
C(OC(=O)[N:7]([CH2:14][CH2:15][O:16][C:17]1[CH:22]=[C:21]([C:23](=[O:31])[N:24]([CH2:28][CH2:29][CH3:30])[CH2:25][CH2:26][CH3:27])[CH:20]=[C:19]([Cl:32])[CH:18]=1)[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)(C)(C)C>ClCCl.FC(F)(F)C(O)=O>[ClH:32].[Cl:32][C:19]1[CH:20]=[C:21]([CH:22]=[C:17]([O:16][CH2:15][CH2:14][NH:7][C:8]2[CH:9]=[CH:10][N:11]=[CH:12][CH:13]=2)[CH:18]=1)[C:23]([N:24]([CH2:28][CH2:29][CH3:30])[CH2:25][CH2:26][CH3:27])=[O:31]

Participants

4

Reactant 1

HCID 53845544HCID 53845544, compound

Product 1

HCID 18349043HCID 18349043, compoundYield 171.1%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of [2-(3-chloro-5-dipropylcarbamoyl-phenoxy)-ethyl]-pyridin-4-yl-carbamic acid tert-butyl ester (0.085 g) in a mixture of dichloromethane (2 ml) and trifluoroacetic acid (2 ml) was stored at room temperature for 18 h and then concentrated under reduced pressure. The residue was triturated with ethereal hydrogen chloride to give the title compound (0.063 g) as a colourless gum.

Workup

  1. concentrationconcentrated under reduced pressure
  2. customThe residue was triturated with ethereal hydrogen chloride

Sources & evidence

ORD record
ord-b4edeb104e254d908bb9543ffbabeaf8
Source dataset
uspto-grants-2001_12
Patent number
US06326386B1

Reaction notes

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