HCID 54430327, compound → HCID 18349222, compound

HRID 2268644Notes

Reaction equation

HRID 2268644 reaction equation
C(OC(=O)[N:7]([CH2:14][CH2:15][O:16][C:17]1[CH:22]=[C:21]([C:23](=[O:33])[N:24]([CH2:31][CH3:32])[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:20]=[C:19]([Cl:34])[CH:18]=1)[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)(C)(C)C>ClCCl.FC(F)(F)C(O)=O>[ClH:34].[Cl:34][C:19]1[CH:20]=[C:21]([CH:22]=[C:17]([O:16][CH2:15][CH2:14][NH:7][C:8]2[CH:9]=[CH:10][N:11]=[CH:12][CH:13]=2)[CH:18]=1)[C:23]([N:24]([CH2:31][CH3:32])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:33]

Participants

4

Reactant 1

HCID 54430327HCID 54430327, compound

Product 1

HCID 18349222HCID 18349222, compoundYield 195%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A solution {2-[3-chloro-5-(ethyl-phenyl-carbamoyl)-phenoxy]-ethyl}-pyridin-4-yl-carbamic acid tert-butyl ester (0.080 g) in a mixture of dichloromethane (1 ml) and trifluoroacetic acid (1 ml) was stored at room temperature for 90 min and then concentrated under reduced pressure. The residue was triturated with ethereal hydrogen chloride to give the title compound (0.068 g) as a colourless solid.

Workup

  1. concentrationconcentrated under reduced pressure
  2. customThe residue was triturated with ethereal hydrogen chloride

Sources & evidence

ORD record
ord-e2e80007e253436fa4ebcc89e74d0d06
Source dataset
uspto-grants-2001_12
Patent number
US06326386B1

Reaction notes

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