Trifluoroacetic acid → HCID 69950592, compound

HRID 2268649Notes

Reaction equation

HRID 2268649 reaction equation
[CH3:1][O:2][C:3](=[O:41])[CH2:4][CH2:5][CH2:6][N:7]([C:15](=[O:40])[C:16]1[CH:21]=[C:20]([Cl:22])[CH:19]=[C:18]([O:23][CH2:24][CH2:25][N:26](C(OC(C)(C)C)=O)[C:27]2[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=2)[CH:17]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[F:14].[F:42][C:43]([F:48])([F:47])[C:44]([OH:46])=[O:45]>ClCCl>[F:42][C:43]([F:48])([F:47])[C:44]([OH:46])=[O:45].[CH3:1][O:2][C:3](=[O:41])[CH2:4][CH2:5][CH2:6][N:7]([C:15](=[O:40])[C:16]1[CH:17]=[C:18]([O:23][CH2:24][CH2:25][NH:26][C:27]2[CH:28]=[CH:29][N:30]=[CH:31][CH:32]=2)[CH:19]=[C:20]([Cl:22])[CH:21]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[F:14]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 54300940HCID 54300940, compound

Product 1

HCID 69950592HCID 69950592, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 4-[{3-[2-(tert-butoxycarbonyl-pyridin-4-yl-amino)-ethoxy]-5-chloro-benzoyl}-(2-fluoro-phenyl)-amino]-butyric acid methyl ester (0.020 g) in a mixture of dichloromethane (1 ml) and trifluoroacetic acid (1 ml) was stored at room temperature for 16 h and then concentrated under reduced pressure to give the title compound (0.022 g) as a colourless gum.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-b8f1a95854b44c4297d41bf7d4810285
Source dataset
uspto-grants-2001_12
Patent number
US06326386B1

Reaction notes

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