Trifluoroacetic acid → 4-((2-Carbamoyl-phenyl)-{3-chloro-5-[2-(pyridin-4-ylamino)-ethoxy]-benzoyl}-amino)-butyric acid methyl ester trifluoroacetate

HRID 2268652Notes

Reaction equation

HRID 2268652 reaction equation
[CH3:1][O:2][C:3](=[O:43])[CH2:4][CH2:5][CH2:6][N:7]([C:17](=[O:42])[C:18]1[CH:23]=[C:22]([Cl:24])[CH:21]=[C:20]([O:25][CH2:26][CH2:27][N:28](C(OC(C)(C)C)=O)[C:29]2[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=2)[CH:19]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14](=[O:16])[NH2:15].[F:44][C:45]([F:50])([F:49])[C:46]([OH:48])=[O:47]>ClCCl>[F:44][C:45]([F:50])([F:49])[C:46]([OH:48])=[O:47].[CH3:1][O:2][C:3](=[O:43])[CH2:4][CH2:5][CH2:6][N:7]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14](=[O:16])[NH2:15])[C:17](=[O:42])[C:18]1[CH:19]=[C:20]([O:25][CH2:26][CH2:27][NH:28][C:29]2[CH:30]=[CH:31][N:32]=[CH:33][CH:34]=2)[CH:21]=[C:22]([Cl:24])[CH:23]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 538483244-[{3-[2-(tert-Butoxycarbonyl-pyridin-4-yl-amino)-ethoxy]-5-chloro-benzoyl}-(2-carbamoyl-phenyl)-amino]-butyric acid methyl ester

Product 1

HCID 699502544-((2-Carbamoyl-phenyl)-{3-chloro-5-[2-(pyridin-4-ylamino)-ethoxy]-benzoyl}-amino)-butyric acid methyl ester trifluoroacetate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 4-[{3-[2-(tert-butoxycarbonyl-pyridin-4-yl-amino)-ethoxy]-5-chloro-benzoyl}-(2-carbamoyl-phenyl)-amino]-butyric acid methyl ester (0.031 g) in a mixture of dichloromethane (1 ml) and trifluoroacetic acid (1 ml) was stored at room temperature for 1 h and then concentrated under reduced pressure to give the title compound (0.032 g) as a colourless gum.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-0ef04df8dd2841379633eb20a6801a99
Source dataset
uspto-grants-2001_12
Patent number
US06326386B1

Reaction notes

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