Trifluoroacetic acid → HCID 18349145, compound

HRID 2268667Notes

Reaction equation

HRID 2268667 reaction equation
C(OC(=O)[N:7]([CH2:14][CH2:15][O:16][C:17]1[CH:22]=[C:21]([C:23](=[O:29])[N:24]([CH:26]([CH3:28])[CH3:27])[CH3:25])[CH:20]=[C:19]([Cl:30])[CH:18]=1)[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)(C)(C)C.[F:32][C:33]([F:38])([F:37])[C:34]([OH:36])=[O:35]>ClCCl>[F:32][C:33]([F:38])([F:37])[C:34]([OH:36])=[O:35].[Cl:30][C:19]1[CH:20]=[C:21]([CH:22]=[C:17]([O:16][CH2:15][CH2:14][NH:7][C:8]2[CH:9]=[CH:10][N:11]=[CH:12][CH:13]=2)[CH:18]=1)[C:23]([N:24]([CH:26]([CH3:28])[CH3:27])[CH3:25])=[O:29]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69948117HCID 69948117, compound

Product 1

HCID 18349145HCID 18349145, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of {2-[3-chloro-5-(isopropyl-methyl-carbamoyl)-phenoxy]-ethyl}-pyridin-4-yl-carbamic acid tert-butyl ester (0.060 g) in dichloromethane (4 ml) and trifluoroacetic acid (4 ml) was stored at room temperature for 2 h and then concentrated under reduced pressure. The residue was subjected to preparative hplc to give the title compound as a yellow gum (0.061 g).

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-5b702493df034169960a1abf04538651
Source dataset
uspto-grants-2001_12
Patent number
US06326386B1

Reaction notes

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