Trifluoroacetic acid → HCID 18348935, compound

HRID 2268684Notes

Reaction equation

HRID 2268684 reaction equation
C(OC(=O)[N:7]([CH2:14][CH2:15][O:16][C:17]1[CH:22]=[C:21]([C:23](=[O:39])[N:24]([CH:35]2[CH2:38][CH2:37][CH2:36]2)[CH2:25][CH2:26][C:27](=[O:34])[NH:28][CH2:29][C:30]([CH3:33])([CH3:32])[CH3:31])[CH:20]=[C:19]([Cl:40])[CH:18]=1)[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)(C)(C)C.[F:42][C:43]([F:48])([F:47])[C:44]([OH:46])=[O:45]>ClCCl>[F:42][C:43]([F:48])([F:47])[C:44]([OH:46])=[O:45].[Cl:40][C:19]1[CH:20]=[C:21]([CH:22]=[C:17]([O:16][CH2:15][CH2:14][NH:7][C:8]2[CH:9]=[CH:10][N:11]=[CH:12][CH:13]=2)[CH:18]=1)[C:23]([N:24]([CH:35]1[CH2:36][CH2:37][CH2:38]1)[CH2:25][CH2:26][C:27](=[O:34])[NH:28][CH2:29][C:30]([CH3:32])([CH3:31])[CH3:33])=[O:39]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 54401596HCID 54401596, compound

Product 1

HCID 18348935HCID 18348935, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of [2-(3-chloro-5-{cyclobutyl-[2-(2,2-dimethyl-propylcarbamoyl)-ethyl]-carbamoyl}-phenoxy)-ethyl]-pyridin-4-yl carbamic acid tert-butyl ester (0.016 g) in a mixture of dichloromethane (1 ml) and trifluoroacetic acid (1 ml) was stored at room temperature for 64 h and then concentrated under reduced pressure to give the title compound (0.012 g) as a colourless gum.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-e9c46642363848b3a9eaea301588635d
Source dataset
uspto-grants-2001_12
Patent number
US06326386B1

Reaction notes

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