HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 18349214, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 69948335 | HCID 69948335 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 18349214 | HCID 18349214 | — |
Reaction Steps
To a solution of 6-[{3-methyl-5-[2-(pyridin-4-ylamino)-ethoxy]-benzoyl}-(isopropyl)-amino]-hexanoic acid trifluoroacetate (0.022 g) in DMF (1 ml) was added HATU® (0.039 g), DIPEA (0.018 ml) and 0.5M ammonia in 1,4-dioxane solution (0.2 ml). The mixture was stirred overnight. The reaction mixture was evaporated under reduced pressure, the residue obtained was subjected to preparative hplc to give the title compound as a colourless oil (0.008 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06326386B1 |
| Source dataset | uspto-grants-2001_12 |
| ORD ID | ord-7698c2af3ac047e1894cf5cc9b1f5c30 |
| Source note | uspto-grants-2001_12 |