Acetonitrile → HCID 131723008, compound

HRID 2268715Notes

Reaction equation

HRID 2268715 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[Br:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C:17]([OH:19])=[O:18].C(#N)C>CC(C)=O>[Br-:11].[C:17]([CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH2:2]1)([OH:19])=[O:18]

Participants

5

Reactant 3

HCID 6342AcetonitrileHCID 7047QuinolineHCID 202106-Bromohexanoic acid

Product 1

HCID 131723008HCID 131723008, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Chinolin (5.2 g, 40 mmol) and 6-bromo-hexanicacid (7.8 g, 40 mmol) was added to 30 ml acetonitrile. The mixture was refluxed under nitrogen atmosphere for three hours and then stirred for 15 hours at room temperature. 50 ml acetone was added and the solution was stirred for further 1 hour. The white precipitate was filtered, washed with acetone (2*10 ml) and dried.

Workup

  1. temperatureThe mixture was refluxed under nitrogen atmosphere for three hours
  2. stirringthe solution was stirred for further 1 hour
  3. filtrationThe white precipitate was filtered
  4. washwashed with acetone (2*10 ml)
  5. customdried

Sources & evidence

ORD record
ord-8a6df3357b184f229e03b423ed5a9a28
Source dataset
uspto-grants-2001_12
Patent number
US06329144B1

Reaction notes

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