Hydrochloric Acid → 2,2-Dimethoxy-1-phenylpropan-1-one

HRID 2268729Notes

Reaction equation

HRID 2268729 reaction equation
CO[CH:3]([O:6][CH3:7])[O:4][CH3:5].Cl.[C:9]1([C:15](=[O:19])C(=O)C)[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[CH3:20]O>>[CH3:7][O:6][C:3]([O:4][CH3:5])([CH3:20])[C:15]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:19]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 9005Trimethyl orthoformateHCID 113631-Phenyl-1,2-propanedione

Product 1

HCID 109978922,2-Dimethoxy-1-phenylpropan-1-one

Conditions

Temperature
22.5 °C

Procedure

1.2 g of trimethoxymethane and 8.7 ml of 25% strength by weight ethanolic HCl solution were added to 14.8 g of 1-phenylpropane-1,2-dione dissolved in 27.5 ml of methanol. The reaction mixture was stirred at 20 to 25° C. for 2 hours, and the solvent was then removed by distillation. The residue was taken up in methyl tert-butyl ether (MTBE) and the solution was washed with water. The organic phases were dried and the solvent removed by distillation. 18.2 g of product were obtained as a clear oil.

Workup

  1. customthe solvent was then removed by distillation
  2. washthe solution was washed with water
  3. customThe organic phases were dried
  4. customthe solvent removed by distillation

Sources & evidence

ORD record
ord-c22967cdd4d44603b8e1d59b3d6719bf
Source dataset
uspto-grants-2001_12
Patent number
US06329359B1

Reaction notes

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