Picolinic acid → HCID 53697089, compound

HRID 2268809Notes

Reaction equation

Cl.C[O:3][C:4](=[O:24])[C@H:5]([CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]2[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:23])=[CH:10][CH:9]=1)[NH2:6].[N:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[C:31](O)=[O:32]>>[N:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[C:31]([NH:6][C@H:5]([C:4]([OH:3])=[O:24])[CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]2[C:21]([Cl:22])=[CH:20][CH:19]=[CH:18][C:17]=2[Cl:23])=[CH:10][CH:9]=1)=[O:32]

Participants

Reactant 2

HCID 1018Picolinic acid

HCID 69806827HCID 69806827, compound

Product 1

HCID 53697089HCID 53697089, compound

Procedure

from O-(2,6-dichlorobenzyl)-L-tyrosine methyl ester hydrochloride and 2-picolinic acid. δH (DMSO-d6) 8.8-8.6 (2H, m), 8.0 (2H, m), 7.7-7.4 (4H, m), 7.14 (2H, d, J 8.7 Hz), 6.92 (2H, d, J 8.7 Hz), 5.15 (2H, s), 4.72 (1H, m), 3.17 (2H, m); m/z (ESI, 60V) 445 (MH+).

Sources & evidence

ORD record: ord-aabf5f4d7abf4d55bd79b206f187f9e5
Source dataset: uspto-grants-2001_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06329372B1

Reaction notes

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