HCID 9927063, compound → Phthalazine, 4-[(3,5-dichloro-4-pyridinyl)methyl]-1,2-dihydro-7-methoxy-

HRID 2268842Notes

Reaction equation

HRID 2268842 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:21])[C:7]=1[CH2:8][C:9]1[C:18]2[C:13](=[CH:14][C:15]([O:19][CH3:20])=[CH:16][CH:17]=2)[CH:12]=[N:11][N:10]=1>C1COCC1>[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:21])[C:7]=1[CH2:8][C:9]1[C:18]2[C:13](=[CH:14][C:15]([O:19][CH3:20])=[CH:16][CH:17]=2)[CH2:12][NH:11][N:10]=1

Participants

3

Reactant 1

HCID 9927063HCID 9927063, compound

Product 1

HCID 9797215Phthalazine, 4-[(3,5-dichloro-4-pyridinyl)methyl]-1,2-dihydro-7-methoxy-Yield 100.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A suspension of 1-(3,5-dichloro-pyridin-4-ylmethyl)-6-methoxy-phthalazine (23.5 g, 73.4 mmoles), prepared as described in example 5, and PtO2 hydrate (0.5 g, 2.2 mmoles) in THF (600 ml) was put in a hydrogenator at room temperature and 2 atmospheres. After 22 hours the mixture was filtered over celite and brought to dryness to give 23.8 g of the title compound (stoichiometric yield). m.p.: 181-183° C.

Workup

  1. customprepared
  2. customwas put in a hydrogenator at room temperature
  3. filtrationAfter 22 hours the mixture was filtered over celite

Sources & evidence

ORD record
ord-4f6b93c86b734c6d913254d007f1374d
Source dataset
uspto-grants-2001_12
Patent number
US06329370B1

Reaction notes

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