反应详情

Under N2, a solution of 3-bromo-6-difluoromethoxy-3H-isobenzofuran-1-one (6.2 g, 22.2 mmoles), prepared as described in example 95, in dry acetonitrile (30 ml) was added with triphenylphosphine (6.4 g, 24.4 mmoles). After 4 hours under reflux the mixture was dried to give a foam which was triturated in ethyl ether overnight, then filtered, washed with ethyl ether and dried to give 11.4 g of the title compound (yield: 95%).

1. temperatureAfter 4 hours under reflux the mixture
2. customwas dried
3. customto give a foam which
4. customwas triturated in ethyl ether overnight
5. filtrationfiltered
6. washwashed with ethyl ether
7. customdried